Brain parenchimal fraction

From the articles presented earlier regarding the influence of cigarettes smoke on the development and the evolution of the multiple sclerosis we came upon an interesting concept called BRAIN PARENCHIMAL FRACTION. Continuing my researches I found out another interesting article with the title: "Standardized Calculation of Brain Parenchymal Fraction: An Approach to Objective Assessment of Cerebral Atrophy" published in the American Journal of Neuroradiology 24:1492-1493, August 2003. The full article can be found here.
In essence brain parenchimal fraction or BPF is a semiautomated segmentation algorithm that combines the values of fractional gray matter (GM) and white matter (WM) volume into the ratio of brain parenchimal volume to total intercranial volume. It is used to estimate the degree of brain atrophy. As the utility in MS field it is mentioned the fact that is "a useful quantitative MR imaging marker for investigating destructive processes ongoing in relapsing-remitting multiple sclerosis and has been applied for intraindividual longitudinal monitoring."

Now that I cleared this point I hope that reading and understanding my posts has become easier. Thanks for your attention and hang on everybody, we've just started the fight!